Other firsts for British Cycling's premier road cycling event include a stage start in the Scottish capital Edinburgh and two stages taking in Northumberland and the north east of England.
Having welcomed the Friends Life Tour of Britain annually since 2010, Wales will play host to the opening stage for the first time in the modern race's history, with a stage which will take in all six regions of North Wales as it heads from Anglesey to Wrexham. It will also be the first time that the race has started on an island.
Stage Two sees the race return to the heart of Lancashire for the first time since 2010, with Ribble Valley and Pendle playing host to a stage from Clitheroe to Colne, which will pass through the Forest of Bowland and Dunsop Bridge, the geographic centre of the United Kingdon.
Cockermouth in Cumbria will be the start venue for the first of two stages to include Scotland, with Stage Three heading through Carlisle, Dumfries & Galloway and the Scottish Borders to the finish in the grounds of Floors Castle at Kelso.
A second Scottish stage will begin from Holyrood Park in Edinburgh, showcasing some of the city's iconic landscapes before heading through the Borders and Northumberland to the finish on the coast in Blyth.
Stage Five will trace Hadrian's Wall from Prudhoe in Northumberland into Cumbria and the Lake District before finishing atop Hartside Fell in the Pennines. At five-miles long and 1,904-feet high, the climb will provide the highest and toughest summit finish in the modern Tour of Britain's history.
Friday 11 September's stage will join two English cities with the peloton racing from Stoke-on-Trent to Nottingham, the latter returning to the route for the first time since 2012.
The penultimate stage will be the longest of the 2015 Friends Life Tour of Britain at 225-kilometres, heading from Fakenham in Norfolk to Ipswich in Suffolk, before the final stage in the centre of London.
The London stage presented by Transport for London will feature an entirely new route in 2015, starting and finishing on Regent Street St James and providing an iconic backdrop for Britain's biggest professional cycle race which will take in Regent Street, Piccadilly Circus, Trafalgar Square, the Strand and Whitehall.
In total eleven venues will welcome the modern Friends Life Tour of Britain for the first time in 2015.